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[目的]:通过测定小鼠血液中非蛋白氮(NPN)含量,确立氯化汞对小鼠急性肾损伤模型,并对肌苷和解毒净保肾作用进行比较。[方法]:16只健康昆明小鼠随机分成4组。其中A组为HgCl损肾组;B组为HgCl+肌苷;C组为解毒净+0.1%HgCl2及D组对照组。24h后处死采血,制备无蛋白血滤液,分别测定血液中非蛋白氮(NPN)含量,从而观察保肾药的作用。[结果]:肌苷和解毒净对氯化汞引起的急性肾损伤都有一定的保护作用。[结论]:解毒净的保肾作用优于肌苷的保肾作用。
[Objective] The research aimed to establish a model of acute renal injury induced by mercuric chloride in mice by measuring the content of non-protein nitrogen (NPN) in mice blood and compare the effects of inosine and detoxification. [Method]: Sixteen healthy Kunming mice were randomly divided into 4 groups. Among them, group A was HgCl damaging kidney group; group B was HgCl + inosine; group C was detoxification net + 0.1% HgCl2 and group D control group. After 24h, the blood was sacrificed and the protein-free filtrate was prepared. The content of non-protein nitrogen (NPN) in the blood was measured respectively to observe the effect of the kidney-invigorating drug. [Result]: Inosine and detoxification net have some protective effects on acute renal injury induced by mercuric chloride. [Conclusion]: The net effect of detoxification net kidney is better than that of inosine.