新生儿颅内出血(ICH)是新生儿期常见的严重疾患,死亡率高,严重者常有神经系统后遗症。近年来ICH常发生在早产儿,其发病率可高达40%～50%。吲哚美辛作为前列腺素合成酶抑制剂,可抑制前列腺素合成,促进血管的收缩,保证外周血管阻力,维持血压稳定,减少脑血流及组织损伤时自由基产 Neonatal intracranial hemorrhage (ICH) is a common and serious illness in the neonatal period, high mortality, severe cases often have nervous system sequelae. In recent years, ICH often occurs in premature children, the incidence rate can be as high as 40% to 50%. As a prostaglandin synthetase inhibitor, indomethacin inhibits prostaglandin synthesis, promotes vasoconstriction, assures peripheral vascular resistance, stabilizes blood pressure, reduces cerebral blood flow and tissue damage free radical production