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目的 探讨血清特异性IgE(sIgE)与儿童变态反应病发病的关系 ,为临床防治提供依据。 方法 采用法玛西亚公司的免疫CAP诊断系统 ,以荧光酶联免疫法测定sIgE。 结果 71例患儿中可查到 5 4例 4 8种变应原阳性的sIgE ,有些患儿对多种变应原呈阳性反应。支气管哮喘患儿阳性检出率为 74 % (37∶5 0 ) ;变应性鼻炎患儿阳性检出率为 6 4 % (7∶11) ;特应性皮炎及湿疹患儿阳性检出率为 80 % (8∶10 )。主要阳性变应原为户尘螨、屋尘、蒿草、烟曲霉等吸入性变应原和鸡蛋白、牛奶、花生、黄豆等食物性变应原。年幼儿组 (3～ 6岁 )以食物性变应原为主 ;年长儿组 (7～ 15岁 )以吸入性变应原为主。对上述 8种变应原的sIgE两组之间定量比较 ,经秩和检验发现吸入性变应原蒿草的sIgE在组间有明显差异 ,年长儿组高于年幼儿组 (P <0 0 5 ) ;食物性变应原牛奶的sIgE在组间有明显差异 ,年幼儿组高于年长儿组 (P <0 0 5 )。结论 上述 8种变应原是引起太原地区儿童变态反应病的主要变应原 ,随年龄增长血清中吸入性变应原的sIgE的阳性率增多 ,食物性变应原的sIgE的阳性率减少 ;sIgE对外源性变态反应病阳性检出率高。
Objective To investigate the relationship between serum-specific IgE (sIgE) and the development of childhood allergic disease and provide evidence for clinical prevention and treatment. Methods Immune CAP diagnostic system of FAMASIA was used to determine sIgE by fluorescence enzyme-linked immunosorbent assay. Results Fifty-four cases of 48 allergen-positive sIgE were found in 71 children. Some children were positive for multiple allergens. The positive rate of children with bronchial asthma was 74% (37:50). The positive rate of children with allergic rhinitis was 64% (7:11). The positive rate of children with atopic dermatitis and eczema 80% (8:10). The main positive allergens were house dust mites, house dust, wormwood, Aspergillus fumigatus and other inhalation allergens and egg white, milk, peanuts, soy and other food allergens. The young children group (3 to 6 years old) mainly food allergens; older children (7 to 15 years old) mainly inhaled allergens. Quantitative comparison of the sIgE of the eight allergens between the two groups showed that the sIgE of inhalational allergens was significantly different between the two groups (P <0 There was a significant difference in the sIgE of food-allergen milk between the two groups, with the difference being higher in young children than in older children (P <0.05). Conclusions The above eight allergens are the major allergens that cause allergic reaction in children in Taiyuan. The positive rate of sIgE of inhaled allergens increases with the increase of age, and the sIgE positive rate of food allergens decreases. sIgE positive rate of exogenous allergic disease detection rate.