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目的探讨三维适形放疗同步替吉奥联合奥沙利铂治疗局部晚期胃癌的疗效。方法 30例局部晚期胃癌采用同步放化疗为放化组,29例采用单纯化疗为化疗组。分析两组近期疗效、生存率及中位生存时间,同时评价治疗期间出现的不良反应。结果放化组近期有效率、生存率及中位生存时间均优于化疗组,比较差异均有统计学意义(P<0.05);治疗期间两组出现Ⅲ～Ⅳ级血液性毒性分别为5例及3例,消化道反应两组均未出现Ⅲ～Ⅳ级恶心、呕吐,两组比较差异无统计学意义(P>0.05)。结论三维适形放疗同步替吉奥联合奥沙利铂治疗局部晚期胃癌的有效率、生存率及中位生存时间较单纯化疗高,不良反应可耐受。
Objective To investigate the efficacy of three-dimensional conformal radiotherapy combined with teliotide and oxaliplatin in the treatment of locally advanced gastric cancer. Methods 30 patients with locally advanced gastric cancer were treated with concurrent radiochemotherapy and radiochemotherapy group. 29 patients were treated with chemotherapy alone. The two groups’ short-term efficacy, survival rate and median survival time were analyzed, and adverse reactions during treatment were evaluated. Results The radiotherapy group had better efficacy, survival rate, and median survival time than the chemotherapy group. The difference was statistically significant (P<0.05). There were 5 cases of grade III-IV hematologic toxicity in both groups during the treatment period. And in 3 cases, gastrointestinal reactions did not show grade III-IV nausea and vomiting, and there was no significant difference between the two groups (P>0.05). Conclusion The efficacy, survival rate and median survival time of three-dimensional conformal radiotherapy synchronotherapy combined with oxaliplatin in the treatment of locally advanced gastric cancer are higher than that of chemotherapy alone, and adverse reactions can be tolerated.