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阿片类物质及其受体在心肌组织中能够产生缺血预适应作用,对抗心肌缺血/再灌注损伤,其机制与Gi/o蛋白、线粒体ATP敏感钾通道、蛋白激酶C、环氧化酶2等都有关。现综述近年来关于阿片类物质参与心肌保护的信号转导及其机制;阿片类物质心肌保护的临床应用及研究进展。
The opioid and its receptor can precondition ischemic preconditioning in myocardial tissue against myocardial ischemia / reperfusion injury. Its mechanism is related to Gi / o protein, mitochondrial ATP sensitive potassium channels, protein kinase C, cyclooxygenase 2 and so on. Now reviewed in recent years on the opioids involved in myocardial protection signal transduction and its mechanism; opioid myocardial protection of clinical application and research progress.