本综述阐述中和抗体同病毒结合导致病毒失去感染性的机理。目前,人们对中和抗体与病毒抗原决定簇之间的相互作用及病毒如何失去感染性的问题了解甚少。过去有关中和作用的理论是建立在逻辑性错误基础上的,认为(1)中和作用服从单一攻击动力学(Single-hit Kinetics),即一个抗体分子能灭活一个感染性病毒颗粒;(2)中和抗体 This review describes the mechanism by which neutralizing antibodies bind to viruses resulting in loss of infectivity by the virus. At present, little is known about the interaction between neutralizing antibodies and viral epitopes and how the virus loses its infectivity. In the past, the theory of neutralization was based on a logical error that (1) neutralization obeys single-hit Kinetics, where one antibody molecule inactivates one infectious virus particle; ( 2) neutralize antibody