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目的探讨淫羊藿苷的脑保护作用。方法采用大脑中动脉线栓法建立小鼠脑缺血-再灌注(I-R)损伤模型,随机分为假手术组、模型组和淫羊藿苷治疗(治疗组),分别于1、3、7、14d行神经功能缺损评分,并分别于再灌注后3、7、14d取新鲜缺血侧脑皮层组织行脑超氧化物歧化酶(SOD)和丙二醛(MDA)含量检测。结果与假手术组相比,模型组及治疗组均出现神经功能缺损症状。与模型组相比,治疗组7和14d时症状改善明显(P<0.05和P<0.01)。模型组SOD值7d和14d下降比治疗组明显(P<0.05和P<0.01),MDA值持续上升。结论淫羊藿苷可能通过抑制氧化应激而对小鼠脑I-R损伤起保护作用。
Objective To investigate the protective effect of icariin on brain. Methods The model of cerebral ischemia - reperfusion (IR) injury was established by middle cerebral artery occlusion (MCAO) in rats. The rats were randomly divided into sham operation group, model group and icariin treatment group (treatment group) , And neurological deficit scores on the 14th day. The levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in the ischemic cortex were measured at 3, 7 and 14 days after reperfusion. Results Compared with the sham operation group, the symptoms of neurological deficit occurred in the model group and the treatment group. Compared with the model group, the treatment group 7 and 14d symptoms improved significantly (P <0.05 and P <0.01). The decrease of SOD in model group at 7d and 14d was more significant than that in the treatment group (P <0.05 and P <0.01), MDA value kept rising. Conclusion Icariin may protect I-R injury in mice by inhibiting oxidative stress.