来得时联合二甲双胍与吡格列酮治疗2型糖尿病临床观察

来源 :中国实用内科杂志 | 被引量 : 0次 | 上传用户:gongshan
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的观察来得时(甘精胰岛素)联合二甲双胍、吡格列酮治疗2型糖尿病患者疗效及安全性。方法将口服降血糖药物血糖控制不佳的2型糖尿病患者随机分为两组,治疗组(来得时组)20例,对照组(诺和灵30R组)22例,来得时组给予睡前皮下注射1次,诺和灵30R组给予早晚餐前皮下注射各1次,两组均联合二甲双胍、吡格列酮,按照空腹血糖(FPG)调整胰岛素用量,治疗目标值FPG<7.0mmol/L,治疗时间12周。观察治疗前后空腹血糖、糖化血红蛋白(HbA1c)、体重变化、低血糖情况。结果治疗后两组患者的空腹血糖、餐后2h血糖均明显低于治疗前各组水平(P<0.05);诺和灵30R组血糖下降水平、BMI变化与来得时组无差异(P>0.05);来得时组低血糖发生率明显低于诺和灵30R组(P<0.01)。结论来得时和诺和灵30R均能使患者血糖达标,来得时组低血糖发生率明显低于诺和灵30R组,更安全、方便,患者依从性更高。 Objective To observe the efficacy and safety of the combination of metformin with metformin and pioglitazone in patients with type 2 diabetes mellitus. Methods 20 type 2 diabetic patients with poorly controlled blood glucose control were randomly divided into two groups: 20 cases in the treatment group (Bordener group) and 22 cases in the control group (Novolin 30R group) Injection twice a day, noradren 30R group was given once a day before breakfast and evening subcutaneous injection, metformin and pioglitazone in both groups were adjusted according to fasting blood glucose (FPG) dosage, the treatment target FPG <7.0mmol / L, treatment time 12 week. Fasting blood glucose, glycosylated hemoglobin (HbA1c), body weight changes and hypoglycemia were observed before and after treatment. Results After treatment, fasting blood glucose and postprandial blood glucose at 2h were significantly lower than those before treatment in both groups (P <0.05). There was no significant difference in the blood glucose level and BMI between the Norvuling 30R group and the control group (P> 0.05) ). The incidence of hypoglycemia in Bordeaux group was significantly lower than that of Novolin 30R group (P <0.01). Conclusions Both propranolol and norrerosine 30R can make patients achieve blood glucose level. The incidence of hypoglycemia in Lidexu group is significantly lower than that of Norvuling 30R group, which is safer, more convenient and patient compliance is higher.
其他文献
目的了解山东省地方性氟中毒改水降氟措施完成情况与病情变化动态。方法按照山东省地方性氟中毒监测方案的要求,对高密等5县市有关地方性氟中毒指标进行调查。结果高密等5县
目的探讨三维CT血管造影(three-dimensional CT angiography,3D-CTA)指导颅内前循环动脉瘤早期夹闭手术的价值。方法自发性蛛网膜下腔出血患者28例均于出血48h内行3D-CTA检查
In early 2013,the novel H7N9 influenza virus was identified as a human-infecting virus in China.The virus causes pneumonia,respiratory failure,acute respiratory
改善胰岛素抵抗以及血运重建治疗冠心病是否改善2型糖尿病合并冠心病患者的预后是尚须解决的临床问题。新近发表在新英格兰杂志的BARI2D研究显示,对于2型糖尿病合并病情稳定
为盘活大学校园里读者的个人资源,充分发挥个人资源的公共效益,有效发掘读者的特色收藏,实现读者个人资源的广泛共享,同时也能够有力补充学校图书馆的馆藏资源,提出以漂书模
骨质疏松症是一种常见的、多发的中老年疾病。据世界卫生组织报道,目前世界上约有2亿多中老年人尤其是妇女患此病;随着人类平均寿命的延长,该病的发病率以每年增长一倍的速度
本文建立了一个存在转换成本的双寡头价格博弈模型,用以解释我国移动通信市场中中国移动和中国联通的价格竞争行为。研究认为,在用户数量增长的市场中,初始市场份额小的企业将制定相对于初始市场份额大的企业更低的价格,博弈的结果会导致初始市场份额大的企业的市场份额下降。
国内外司法实践表明,图书馆在使用著作权中能否履行合理注意义务,是判断其行为是否构成侵权,以及承担何种法律责任的重要标准。文章介绍了部分与图书馆履行合理注意义务相关
1986年前,我国恙虫病仅知流行于浙江省及其以南地区,主要属夏季型,以地里纤恙螨为主要媒介。1986年在江苏、山东发生恙虫病流行,属秋冬型。此后,在天津、山西、河北、河南、
Inflammatory bowel disease(IBD)is a group of chronic disorders of the gastrointestinal tract comprising Crohn’s disease(CD)and ulcerative colitis(UC).Their eti