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目的探讨贞芪扶正颗粒联合芪舌饮治疗胰腺癌疗效及对炎性因子白细胞介素-6(IL-6)、白细胞介素-10(IL-10)及肿瘤坏死因子α(TNF-α)水平的影响。方法将60例胰腺癌术后患者随机分为2组,对照组予对症处理、化疗基础上给予贞芪扶正颗粒治疗,观察组于对照组治疗基础上联合芪舌饮治疗,观察2组治疗前后中医证候积分及血清IL-6、IL-10、TNF-α水平变化情况,统计2组不良反应发生情况。结果 2组治疗后纳呆、食少、神疲乏力、身目发黄、便溏、腹胀、烦热积分均显著低于治疗前(P均<0.05),且观察组治疗后各项积分均显著低于对照组(P均<0.05);2组治疗后IL-6、IL-10及TNF-α水平均低于治疗前(P均<0.05),且观察组治疗后IL-6、IL-10及TNF-α水平均显著低于对照组(P均<0.05);2组不良反应发生率比较差异无统计学意义(P>0.05)。结论贞芪扶正颗粒联合芪舌饮治疗胰腺癌疗效较佳,可有效改善中医证候评分,且降低炎性因子水平,并未增加不良反应发生率,具有重要临床价值。
Objective To investigate the curative effect of Zhenqi Fuzheng granule combined with Qi tongue drink on pancreatic cancer and its effect on the expression of interleukin-6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor-α (TNF- Horizontal impact. Methods Sixty patients with postoperative pancreatic cancer were randomly divided into two groups. The control group was given symptomatic treatment. On the basis of chemotherapy, Zhenqi Fuzheng Granule was given. The observation group was treated with Qijiao Decoction on the basis of the control group. TCM syndrome scores and serum IL-6, IL-10, TNF-α levels, statistical group 2 adverse reactions. Results After treatment, the patients in the two groups had significantly lower scores of appetite, food less, fatigue, body yellow, loose stools, bloating and annoyance than those before treatment (all P <0.05) (P <0.05). The levels of IL-6, IL-10 and TNF-αin two groups were lower than those before treatment (all P <0.05), and the levels of IL-6, IL -10 and TNF-α were significantly lower than those in the control group (all P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Zhenqi Fuzheng granule combined with Qi tongue drink in the treatment of pancreatic cancer is better, which can effectively improve TCM syndrome score, and reduce the level of inflammatory factors, did not increase the incidence of adverse reactions, has important clinical value.