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目的探讨胸腔积液中腺苷脱氨酶(ADA)、乳酸脱氢酶(LDH)、癌胚抗原(CEA)、肿瘤抗原19-9 (CA19-9)、肿瘤抗原125(CA125)联合检测在胸腔积液鉴别诊断中的意义。方法常规采集各80例结核性疾病组和恶性疾病组胸腔积液,测定胸腔积液ADA、LDH、CEA、CA125、CA19-9等五项指标,并进行对比分析。结果联合检测对结核性胸腔积液诊断的敏感度为92.5%、特异度为93.6%、准确度为92.7%;对恶性胸腔积液诊断的敏感度、特异性、准确度分别为92.3%、94.6%、93.5%。结论联合检测多项指标有效地避免了单一指标检测所致的误诊和漏诊,有助于胸腔积液的病因诊断。
Objective To investigate the combination of adenosine deaminase (ADA), lactate dehydrogenase (LDH), carcinoembryonic antigen (CEA), tumor antigen 19-9 (CA19-9) and tumor antigen 125 Significance of differential diagnosis of pleural effusion. Methods Eighty patients with tuberculosis and malignant disease were routinely collected for pleural effusion. Five indicators of ADA, LDH, CEA, CA125 and CA19-9 in pleural effusion were determined and compared. Results The sensitivity, specificity and accuracy of combined detection for the diagnosis of tuberculous pleural effusion were 92.5%, 93.6% and 92.7%, respectively. The sensitivity, specificity and accuracy were 92.3% and 94.6 respectively %, 93.5%. Conclusion Combined detection of multiple indicators effectively avoid the misdiagnosis and missed diagnosis caused by a single index test, which is helpful to the etiological diagnosis of pleural effusion.