难治性高血压定义为尽管使用≥5种不同的抗高血压药物,包括氯噻酮和螺内酯,血压仍未得到控制。最近的研究表明,难治性高血压并不常见,仅5%~10%的患者因为血压得不到控制被转诊至高血压专科诊所。白大衣效应指的是自动诊室血压≥135/85mm Hg(1mm Hg=0.133kPa),而诊室外清醒时动态血压监测血压<135/85 mm Hg,占所有高血压患者的30%~40%。而难治性高血压患者中白大衣效应的发 Refractory hypertension is defined as blood pressure not yet controlled despite the use of ≥5 different antihypertensive drugs, including chlorthalidone and spironolactone. Recent studies have shown that refractory hypertension is uncommon and that only 5% to 10% of patients are referred to an intensive care unit because blood pressure is not controlled. White coat effect refers to the automatic office pressure ≥ 135 / 85mm Hg (1mm Hg = 0.133kPa), while ambulatory outside awake ambulatory blood pressure monitoring blood pressure <135/85 mm Hg, accounting for 30% to 40% of all hypertensive patients. The treatment of hypertensive patients with white coat effect hair