低氧是实体瘤微环境的基本特征之一,也是导致实体瘤对放疗和化疗产生耐受的原因之一。近年来将低氧作为抗肿瘤靶点的研究十分热门。现综述低氧与肿瘤耐药及肿瘤治疗的研究状况。 Hypoxia is one of the basic characteristics of the solid tumor microenvironment, which is also one of the reasons that solid tumors are resistant to radiotherapy and chemotherapy. In recent years, hypoxia as a target of anti-tumor research is very popular. Now review the hypoxia and tumor drug resistance and cancer treatment research.