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目的 :观察胃肠舒泰颗粒 (胃肠舒泰 )对正常小鼠大肠推进和对吗啡引起的小鼠小肠推进功能抑制的影响 ,以及对正常大鼠胃液分泌和在体兔肠平滑肌的影响。方法 :昆明小鼠 110只 ,对小鼠大肠推进及对吗啡引起的小肠推进 ,分别随机分为 5及 6组 :阴性对照组、(模型对照组 )和胃肠舒泰小、中、大剂量组与普瑞博思组 ,观察各组大肠推进率及以吗啡为抑制剂的小肠推进率 ;SD大鼠 5 0只 ,分 5组 ,观察该药对大鼠胃液分泌的影响 ;大耳白兔 4 0只 ,观察该药对在体兔肠平滑肌的影响。结果 :胃肠舒泰可促进正常小鼠大肠推进率 ,不能拮抗吗啡引起的小鼠小肠推进 ,可升高正常大鼠胃蛋白酶排出量及增强兔肠平滑肌运动的频率与幅度。结论 :胃肠舒泰具有促胃肠动力作用 ,并可升高正常大鼠胃蛋白酶排出量 ,这可能是其治疗胃肠动力障碍性消化不良疾病的药理学基础之一。
Objective: To observe the effect of Weichangshutai granules (Gaichangshutai) on the progression of large intestine in normal mice and the inhibition of small intestine advancing function induced by morphine in mice, and the effect on gastric juice secretion and rabbit intestinal smooth muscle in normal rats. METHODS: A total of 110 Kunming mice were enrolled in the mice for large intestine advancing and morphine-induced small intestine advancing. They were randomly divided into 5 and 6 groups: negative control group, model control group, and small, medium, and large doses of Weishutai. Group and Prizows group, observing the propulsion rate of large intestine of each group and the small intestine advancing rate with morphine as an inhibitor; 50 SD rats were divided into 5 groups to observe the effect of the drug on rat gastric secretion; big white rabbit Forty birds were observed for the effect of the drug on rabbit intestinal smooth muscle. RESULTS: Weichang Shutai can promote the rate of large intestine advancing in normal mice, and it can not antagonize morphine-induced small intestine advancing. It can increase pepsin excretion and increase the frequency and amplitude of rabbit intestinal smooth muscle movement. Conclusion : Weichangshutai has the effect of promoting gastrointestinal motility and increasing the excretion of pepsin from normal rats, which may be one of the pharmacological basis for the treatment of gastrointestinal dysmotility disorders.