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用记录膈神经和膈肌的呼吸性发放的方法,对新疆中介蝮(A.intermedius Strauch)蛇毒急性中毒引起的呼吸麻痹,分别用家兔和大白鼠进行了实验分析。将稍大于最小致死量(0.1mg/kg 体重)的中介蝮蛇毒,经静脉或肌肉注入动物体内,一般经数小时后出现软瘫性呼吸麻痹,若及时地给予人工呼吸,则在膈肌的呼吸性发放完全停止的情况下,心电和膈神经的呼吸发放都尚可维持相当长的时间。若将蝮蛇毒直接注入侧脑室内,甚直达每公斤体重30-50微克,不引起动物出现明显的呼吸困难。若将脑室注射量加大每公斤体重100mg以上,则动物经一定时间出现4肢僵直,头后仰,抽搐等症状而死亡。在离体标本上,蝮蛇毒具有不可逆地阻遏接头传递的阻遏过程相似。
Respiratory paralysis caused by acute poisoning of A.intermedius Strauch snake venom was recorded in respiratory system of phrenic nerve and diaphragm in rabbits and rats. Medication venom slightly larger than the minimum lethal dose (0.1mg / kg body weight), intravenous or intramuscular injection of animals, usually after a few hours of soft-paralysis respiratory paralysis, if timely artificial respiration, the respiration of the diaphragm Sexual release and the release of the phrenic nerve can still be maintained for a long time if the condition is completely stopped. If viper poison directly into the lateral ventricle, up to 30-50 micrograms per kilogram of body weight, does not cause obvious respiratory difficulties in animals. If the intraventricular injection volume increase per kg body weight 100mg or more, the animals after a certain period of limb stiffness, head back, convulsions and other symptoms and death. On isolated specimens, Agkistrodon acutus has a similar blocking process that irrevocably blocks adapter delivery.