本文报告应用扶正固本丸对小鼠肠道内与人类关系密切的主要菌群的影响。用大黄水煎液灌胃予小鼠,造成实验性脾虚模型,引起小鼠肠道内菌群紊乱,其中双歧杆菌,乳杆菌量均下降,与对照组相比有显著性差异。当服用扶正固本丸后,双歧杆菌、乳杆菌均上升至正常水平。本研究表明,扶正固本丸对小鼠肠道菌群失调具有一定的调整作用。 This article reports the effect of the use of Fuzheng Guben Pill on the main flora in the human gut that is closely related to humans. Rhubarb decoction was used to intragastrically administrate the mice, resulting in an experimental spleen deficiency model, which caused the intestinal flora to be disordered in the mice. The amount of Bifidobacterium and Lactobacillus decreased, and there was a significant difference compared with the control group. After taking Fuzheng Guben Pill, both Bifidobacterium and Lactobacillus rose to normal levels. This study shows that Fuzheng Gubenwan has a certain adjustment effect on the imbalance of intestinal flora in mice.