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目的探讨孕期妇女职业接触全氟化合物(PFCs)与不良妊娠结局之间的关联性,为生殖健康及妇幼保健工作提供参考依据。方法选取2013年1~11月在贵阳医学院附属医院产前诊断中心进行产检的孕产妇640例,对其进行问卷调查,了解其在孕期经职业接触PFCs的相关信息以及妊娠结局情况。结果孕产妇是否发生不良妊娠结局在从事服装、皮革、家具防污剂、涂料装修、印刷品、纸质包装职业方面比较,差异有统计学意义(P<0.05);而在从事地毯、合成洗涤剂、防水材料职业方面比较,差异无统计学意义(P>0.05)。Logistic回归分析结果显示,从事服装(OR=3.131)、印刷(OR=3.495)职业是不良妊娠结局的危险因素,其他因素与不良妊娠结局均无关(P>0.05)。结论孕期女性应尽量避免从事与PFCs有关的职业,同时相关部门应重视PFCs的危险性,尽量减少PFCs的污染,降低不良妊娠结局的发生率。
Objective To explore the correlation between occupational exposure to perfluorocompounds (PFCs) and adverse pregnancy outcome in pregnant women and to provide reference for reproductive health and maternal and child health care. Methods Six hundred and seventy-four pregnant women were examined at prenatal diagnosis center of Affiliated Hospital of Guiyang Medical College from January to November in 2013. Questionnaires were conducted to find out the related information about occupational exposure to PFCs during pregnancy and the outcome of pregnancy. Results Maternal adverse pregnancy outcome in engaged in clothing, leather, furniture antifouling agents, paint decoration, print, paper packaging occupations, the difference was statistically significant (P <0.05); while engaged in carpet, synthetic detergent , Waterproof material occupational aspects, the difference was not statistically significant (P> 0.05). Logistic regression analysis showed that occupational occupations in clothing (OR = 3.131) and printing (OR = 3.495) were risk factors for adverse pregnancy outcomes. Other factors were not associated with adverse pregnancy outcomes (P> 0.05). Conclusions During pregnancy, women should avoid engaging in occupations related to PFCs. At the same time, relevant departments should pay attention to the risk of PFCs, minimize the pollution of PFCs and reduce the incidence of adverse pregnancy outcomes.