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目的:评价自拟停颤汤联合多巴丝肼片治疗中早期帕金森病（Parkinson disease，PD）阴虚风动证临床疗效。方法:将符合入选标准的2020年1月－2021年3月山东省潍坊市中医院84例中早期PD患者按随机数字表法分为2组，每组42例。对照组口服多巴丝肼片，观察组在对照组基础上加用自拟停颤汤。2组均治疗8周。分别于治疗前后进行中医证候评分，采用统一帕金森病评定量表（Unified Parkinson Disease Rating Scale，UPDRS）评估PD病情严重程度；采用ELISA法测定血清同型半胱氨酸（Hcy）、高迁移率族蛋白-1（HMGB1）、IL-6、IL-2、P物质及多巴胺（DA）水平；采用HPLC法检测谷氨酸（Glu）、γ-氨基丁酸（GABA）水平；采用超微量分光光度计测定OD值，以2n -??Ct法计算微小核糖核酸-124（miR-124）和微小核糖核酸-425（miR-425）相对表达量，评价临床疗效。n 结果:观察组总有效率为88.1%（37/42）、对照组为73.8%（31/42），2组比较差异有统计学意义（n Z=-2.56，n P=0.011）。观察组治疗后动作评分、震颤评分、上肢协调评分、步态评分及UPDRS评分低于对照组（n t值分别为7.23、5.80、4.25、4.17、15.00，n P值均<0.001）。治疗后，观察组血清Hcy、HMGB1、IL-6、IL-2水平低于对照组（n t值分别为12.16、10.67、23.11、9.95，n P<0.01），Glu［（71.28±6.46）μmol/L比（56.91±5.87）μmol/L，n t=10.67］、GABA［（292.39±15.46）μmol/L比（248.51±14.38）μmol/L，n t=13.47］水平高于对照组（n P<0.01）；P物质［（3.54±0.43）mg/L比（5.61±0.52）mg/L，n t=19.88］低于对照组（n P<0.01），DA［（79.24±5.15）ng/L比（70.15±5.36）ng/L，n t=7.93］水平及miR-124［（4.57±0.74）比（2.81±0.47），n t=13.01］、miR-425［（3.94±0.83）比（2.73±0.97），n t=6.14］相对表达量高于对照组（n P<0.01）。n 结论:自拟停颤汤联合多巴丝肼片可通过升高PD患者血清miR-124和miR-425相对表达量，促进DA释放，减轻大脑氧化应激反应，降低血清炎性细胞因子水平，改善症状，保护神经细胞。“,”Objective:To evaluate the clinical efficacy of self-made Tingchan Decoction combined with dopasizin tablets in the treatment of Parkinson disease (PD) in the middle and early stages of yin deficiency and wind movement syndrome.Methods:From January 2020 to March 2021, 84 patients with early-stage PD in Weifang Hospital of Traditional Chinese Medicine in Shandong Province who met the inclusion criteria were divided into 2 groups according to the random number table method, with 42 in each group. The control group was given oral dopasehydrazine tablets, and the observation group and the control group were additionally given the self-made Tingchan Decoction. Both groups were treated for 8 weeks. TCM syndrome scores were performed before and after treatment, and the Unified Parkinson Disease Rating Scale (UPDRS) was used to evaluate the severity of PD. The ELISA was used to determine serum homocysteine (Hcy), high mobility the levels of group protein-1 (HMGB1), IL-6, IL-2, substance P and dopamine (DA). The levels of glutamate (Glu) and γ-aminobutyric acid (GABA) were detected by HPLC. The OD value was determined by photometer, and the relative expression levels of microRNA-124 (miR-124) and microRNA-425 (miR-425) were calculated by the 2n -??Ct method to evaluate the clinical efficacy.n Results:The total effective rate was 88.1% (37/42) in the observation group and 73.8% (31/42) in the control group, and the difference between the two groups was statistically significant (n Z=-2.56, n P=0.011). after treatment, the action score, tremor score, upper limb coordination score and gait score in the observation group were significantly lower than those in the control group (n t values were 7.23, 5.80, 4.25, 4.17, 15.00,respectively, all n Ps<0.01). After treatment, the levels of serum Hcy, HMGB1, IL-6 and IL-2 in the observation group were significantly lower than those in the control group (n t values were 12.16, 10.67, 23.11, 9.95, respectively, all n Ps<0.01), serum Glu [(71.28±6.46) μmol/Ln vs. (56.91±5.87) μmol/L, n t=10.67], GABA [(292.39±15.46) μmol/L n vs. (248.51±14.38) μmol/L, n t=13.47] levels in the observation group were significantly higher than those in he control group (n P<0.01); the level of serum substance P [(3.54±0.43) mg/Ln vs. (5.61±0.52) mg/L,n t=19.88] was significantly lower than that of the control group (n P<0.01). The DA [(79.24±0.52) ng/Ln vs. (70.15±5.36) ng/L, n t=7.93] and miR-124 [(4.57±0.74) n vs. (2.81±0.47), n t=13.01], miR-425 [(3.94±0.83) n vs. (2.73±0.97), n t=6.14] expression in the observation group were significantly higher than those in the control group (n P<0.01).n Conclusion:Self-made Tingchan Decoction combined with dobasilazine can increase the relative expression of miR-124 and miR-425 in the serum of PD patients, promote the release of dopamine, reduce the oxidative stress in the brain, reduce the level of serum inflammatory cytokines, improve the Symptoms, and protect nerve cells.