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目的:回顾性分析晚期癌痛患者由口服吗啡控释片转换为芬太尼透皮贴剂镇痛的疗效。方法:38例口服吗啡控释片镇痛不理想的晚期癌痛患者,转换为芬太尼透皮贴剂,吗啡与芬太尼贴剂的剂量换算比为100∶1。采用疼痛强度数字评分法(NRS)对疼痛进行评价,根据患者的主观感受将疼痛的程度由轻至重分为0~10分,若评分降低>2,则认为疼痛显著缓解,并观察患者不良反应发生的情况。结果:药物转换后显著缓解患者的疼痛,疼痛强度评价由转换前的(6.3±1.2)分降低到(3.1±0.6)分,而不良反应的发生率由转换前的94.7%减少到57.9%,差异有统计学意义(P<0.05或0.01)。结论:将吗啡控释片转换为芬太尼透皮贴剂是一种安全可靠、效果显著的镇痛策略。
OBJECTIVE: To retrospectively analyze the curative effect of oral morphine controlled-release tablets to fentanyl transdermal patches in patients with advanced cancer pain. METHODS: Thirty-eight patients with poorly controlled analgesia of oral morphine controlled-release tablets were converted to fentanyl transdermal patches and the dose conversion ratio of morphine to fentanyl patch was 100: 1. The pain was evaluated using NRS and the pain was assessed as subjective to 0-10 according to the patient’s subjective perception. If the score was> 2, the pain was relieved and the patient was assessed for poor outcome The reaction occurred. Results: The pain relief was significantly relieved after drug conversion. The assessment of pain intensity decreased from 6.3 ± 1.2 before conversion to 3.1 ± 0.6 while the incidence of adverse reactions decreased from 94.7% before conversion to 57.9% The difference was statistically significant (P <0.05 or 0.01). CONCLUSION: Conversion of morphine controlled-release tablets to fentanyl transdermal patches is a safe and effective analgesic strategy.