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目的；探讨子宫内膜腺癌发生与细菌L型感染和p53蛋白表达的关系。方法：用革兰染色和免疫组化染色技术对102例子宫内膜腺癌、30例基本正常子宫内膜进行细菌L型和p53蛋白检测。结果：腺癌组的细菌L型检出率为81．4％，与基本正常组的细菌L型检出率（800％）无显著性差异（P＞0．05）。但腺癌组的p53表达率（50％）却高于基本正常组（3．3％，P＜0．05）；腺癌组中细菌L型阳性伴p53表达率也高于细菌L型阳性件p53表达率（P＜0．05）。表明子宫内膜腺癌与细菌L型感染和p53过高表达均有关。结论：细菌L型感染可能引起p53基因突变，从而参与了导致子宫内膜腺癌的作用。
Objective To investigate the relationship between endometrial adenocarcinoma and bacterial L-type infection and p53 protein expression. Methods: The bacterial L-type and p53 proteins were detected in 102 cases of endometrial adenocarcinoma and 30 cases of normal endometrium by Gram stain and immunohistochemistry. Results: The detection rate of bacterial L type in adenocarcinoma group was 81.4%, which was not significantly different from that in the normal group (800%) (P> 0.05). However, the positive rate of p53 expression in adenocarcinoma group was higher than that in normal group (3.3%, P <0.05) P53 expression (P <0.05). That endometrial adenocarcinoma and bacterial L-type infection and p53 are over-expression. Conclusion: L type bacterial infection may cause p53 gene mutation, which is involved in the role of endometrial adenocarcinoma.