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目的探讨环氧化酶2(COX2)在鼻息肉组织中的表达及意义。方法采用免疫组织化学ABC法对48例鼻息肉(按鼻窦炎鼻息肉临床分型分期标准分为A、B两组,A组包括Ⅱ型1、2期鼻窦炎鼻息肉共27例;B组包括Ⅱ型3期及Ⅲ型鼻窦炎鼻息肉共21例)和30例正常下鼻甲黏膜中COX2的表达进行检测。结果COX2在鼻息肉中的表达明显高于正常下鼻甲黏膜(P<0.05),而B组鼻息肉中COX2的表达亦高于A组鼻息肉(P<0.05)。结论COX2在鼻息肉组织中的高表达可能是鼻息肉发生、发展诸多因素中的重要因素之一。
Objective To investigate the expression of cyclooxygenase 2 (COX2) in nasal polyps and its significance. Methods 48 cases of nasal polyps were divided into group A and group B according to the clinical staging criteria of sinusitis and nasal polyps by immunohistochemical ABC method. Group A included 27 cases of type Ⅱ, Including type Ⅱ 3 and type Ⅲ sinusitis and nasal polyps in 21 cases) and 30 cases of normal nasal mucosa COX2 expression were detected. Results The expression of COX2 in nasal polyps was significantly higher than that in normal inferior turbinate mucosa (P <0.05), while the expression of COX2 in group B was higher than that in group A (P <0.05). Conclusion The high expression of COX2 in nasal polyps may be one of the important factors in the development of nasal polyps.