在新药研究中,找到疾病特异靶向的化学实体以得到更为完全、更为有效的药物是至关重要的,但是对于很多疾病,尤其是涉及多靶点通路和网络调控的多样性疾病如肿瘤,由于疾病机制的异常复杂性及病人的多种应答表型,使得药物特异性和个体给药非常困难,往往需要组合的方法设计筛选,从 In new drug research, finding disease-specific chemical entities targeted for more complete and effective drugs is crucial, but for many diseases, especially those involving multiple target pathways and network regulation, such as Tumors, because of the extraordinary complexity of the disease mechanisms and the patient’s multiple phenotype of response, make drug specificity and individual administration very difficult and often require a combination of methodological design screening