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近十年来人们对妊娠期间服用抗癫痫药的母亲所生育的子女先天性畸形发生率增加的可能性予以了显著关注,由于妊娠期间没有服任何抗癫痫药的癫痫母亲的子女先天性畸形发生率也增加,因而使上述见解复杂化.本文目的在于阐明,按目前已知的癫痫分类,在癫痫的性质方面抗癫痫药物可能的致畸胎作用.从门诊就诊的总共将近5000名病人中精选出428名有可能妊娠的各种癞痫妇女,年龄从16至40岁,了解了妊娠及抗癫痫治疗的经过.分类按国际标准,畸胎标准按Okuma等的分类.主要采用回顾性方法.结果428例癫痫女性成年病人,以继发性大发作
The incidence of congenital malformations in children born to mothers who take antiepileptic drugs during pregnancy has been significantly concerned over the past decade as the incidence of congenital malformations in children with epilepsy without any antiepileptic drug during pregnancy Also increased, thus complicating the above insight.The purpose of this paper is to elucidate the possible teratogenic effects of antiepileptic drugs in the nature of epilepsy according to the currently known classification of epilepsy: A total of nearly 5,000 patients selected from outpatient settings A total of 428 pregnant women with epilepsy who are likely to have pregnancy were aged from 16 to 40 years old to understand the course of pregnancy and antiepileptic treatment Classification According to international standards, the standard of teratology was categorized according to Okuma’s method, mainly using a retrospective approach. Results 428 cases of epilepsy female adult patients, with secondary major episode