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为了探讨α干扰素（ＩＦＮα）中和抗体（ＮＡ）在病毒性肝炎患者中的发生率及其时间变化规律性，采用抗病毒中和生物测定法（ＡＮＢ）检测了３２例健康人和１１６例ＩＦＮα治疗的慢性病毒性肝炎患者血清中的ＮＡ。结果健康人及ＩＦＮ治疗前患者血清中未检出ＮＡ，而ＩＦＮ治疗后患者共有２０例ＮＡ阳性，总检出率为１７．２％。其中ＩＦＮα２ａ、ＩＦＮα２ｂ、ＩＦＮα１ｂ治疗组ＮＡ阳性率分别为３４．６％、１３．２％和１１．５％。ＮＡ出现的时间变化随治疗时间的增加，阳性率逐渐递增。提示病毒性肝炎患者ＩＦＮα治疗后可产生ＮＡ，且具有一定的时间规律性。不同亚型的ＩＦＮα治疗后ＮＡ发生率不同。
In order to investigate the incidence and time variation of neutralizing antibodies (IFNα) in patients with viral hepatitis, 32 healthy subjects and 116 healthy subjects were tested by antiviral neutralization bioassay (ANB) NA in serum of patients with chronic viral hepatitis treated with IFNα. Results No NA was detected in serum of healthy people and patients before IFN treatment. However, 20 patients with NA were positive after IFN treatment, with a total detection rate of 17.2%. The positive rates of NA in IFNα2a, IFNα2b and IFNα1b groups were 34.6%, 13.2% and 11.5% respectively. The time of NA appeared with the increase of treatment time, the positive rate gradually increased. It is suggested that NAA can be produced after IFNα treatment in patients with viral hepatitis and has certain regularity of time. Different subtypes of IFNα NA incidence after treatment.