Objective:To reveal the trend in alterations of sperm counts in Asian men over the past 50 years.Methods:This study reviewed all the published reports to unveil the specific patt of alterations of sperm concentrations in Asian men from 1965 till 2015. The time-related changes in sperm concentration were studied using linear regression analyses.Results:The present study elucidated the trend using the reports from Carlsenet al(1965-1990) and non-Carlsen studies published until 2015, on fertile Asian men. In the reports of Carlsenet al., no overall declining trend in Asian men (r = 0.509,P= 0.760) was observed during this tenure, but non-Carsen reports showed a significant time-dependent decline of sperm concentration (r = -0.754, P = 0.005) in Asian men. This present review also showed a mild time-dependant decline in sperm concentration (-0.44×106/mL/year, 95％ CI: -0.65 to -0.23; r = -0.473,P = 0.040) which accounted for an overall 22.17％ decrease in past 50 years.Conclusions:This study brings to the forefront that sperm concentration among Asian men follows a mild declining trend over the period of 50 years, and further studies addressing the causes of this decline are required.