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单增李斯特菌(Listeria monocytogenes,LM)感染可导致人和动物李斯特菌病的发生,当机体受到单增李斯特菌感染后,胞质中的模式识别受体如NOD样受体和DNA/RNA感受器通过识别细菌的病原相关分子模式和毒力因子形成炎性体进行免疫防御。研究证实,细胞内的NLRP3、AIM2、NLRC4、RIG-I、NOD1/NOD2炎性体可分别感知单增李斯特菌的溶血素O、细菌DNA、鞭毛蛋白、菌体RNA及细菌肽聚糖碎片后被激活,促进促炎性因子白细胞介素(Interleukin,IL)-1β和IL-18的表达、成熟和分泌,诱导组织炎症和细胞的免疫应答,同时导致细胞快速死亡。本文对上述问题就国内外最新研究进展进行综述和探讨。
Infection with Listeria monocytogenes (LM) can lead to the development of Listeriosis in humans and animals. When the body is infected with Listeria monocytogenes, the pattern recognition receptors in the cytoplasm, such as NOD-like receptors and DNA / RNA sensor immune defense by recognizing the pathogen-associated molecular patterns of bacteria and virulence factors to form inflammasomes. Studies have shown that intracellular NLRP3, AIM2, NLRC4, RIG-I and NOD1 / NOD2 inflammasomes can respectively detect Lysozyme O, bacterial DNA, flagellin, bacterial RNA and bacterial peptidoglycan fragments of Listeria monocytogenes Is activated to promote the expression, maturation and secretion of the proinflammatory cytokines Interleukin (IL) -1β and IL-18, inducing tissue inflammation and cellular immune responses, leading to rapid cell death. This article reviews and discusses the latest research developments both at home and abroad.