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在磷酸介质中,钒酸铵与盐酸氯丙嗪反应生成红色氧化产物,其最大吸收波长为524nm;据此建立了测定盐酸氯丙嗪含量的钒酸铵氧化-分光光度法,并将其用于直接测定药物制剂中的盐酸氯丙嗪.结果表明,当盐酸氯丙嗪的浓度处于10.0～100mg/L和100～360mg/L范围内时,被测定体系的吸光度与盐酸氯丙嗪的浓度之间呈良好的线性关系;线性回归方程分别为A=-0.061 69+0.010 05c(mg/L,r=0.998 8)、A=0.494+0.004 43c(mg/L,r=0.998 8),检出限为1.96mg/L,相对标准偏差为0.29%,回收率为94.9%～102.9%.
In the phosphoric acid medium, ammonium vanadate reacts with chlorpromazine hydrochloride to form a red oxidation product with a maximum absorption wavelength of 524 nm. Based on this, an ammonium vanadate oxidation-spectrophotometric method for the determination of chlorpromazine hydrochloride content was established and used The results showed that when the concentration of chlorpromazine hydrochloride was in the range of 10.0-100 mg / L and 100-360 mg / L, the absorbance of the tested system and the concentration of chlorpromazine hydrochloride The linear regression equation was A = -0.061 69 + 0.010 05c (mg / L, r = 0.998 8), A = 0.494 + 0.004 43c (mg / L, r = 0.998 8) The limit of detection was 1.96 mg / L with the relative standard deviation of 0.29% and the recovery of 94.9% -102.9%.