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目的探讨胰岛素泵短期强化治疗妊娠糖尿病的临床疗效。方法选取泰和县澄江镇文田卫生院2014年10月—2016年10月收治的妊娠糖尿病患者138例,随机将患者分为对照组与观察组,各69例。对照组予以人型胰岛素治疗,观察组予以便携式丹纳胰岛素泵短期强化治疗,比较两组患者空腹血糖(FBG)、餐后2 h血糖(2h PBG)、胰岛素用量、血糖恢复参考值时间,观察两组患者并发症发生情况(胎儿窘迫、羊水过多、妊娠高血压、低血糖、早产、产后出血)和新生儿并发症发生情况[胎儿生长受限(FGR)、巨大儿、畸形、窒息、低血糖、反射性交感神经营养不良综合征(RSD)]。结果治疗前两组患者FBG、2h PBG比较,差异无统计学意义(P>0.05);治疗后观察组患者FBG、2h PBG低于对照组(P<0.05)。观察组患者胰岛素用量少于对照组,血糖恢复参考值时间短于对照组(P<0.05)。观察组患者并发症发生率低于对照组(P<0.05)。观察组新生儿并发症发生率低于对照组(P<0.05)。结论胰岛素泵短期强化治疗妊娠糖尿病的临床疗效确切,可有效控制血糖水平,降低患者和新生儿并发症发生率。
Objective To investigate the short-term intensive insulin therapy of gestational diabetes mellitus clinical efficacy. Methods A total of 138 gestational diabetes patients admitted to Wentian Hospital, Chengjiang Town, Taihe County from October 2014 to October 2016 were randomly divided into control group and observation group, with 69 cases each. The control group was treated with human insulin, and the observation group was treated with portable Dana insulin pump for short-term intensive treatment. The fasting blood glucose (FBG), 2 h postprandial blood glucose (2 h PBG), insulin dosage, blood glucose recovery reference time were compared between two groups Complications (fetal distress, polyhydramnios, gestational hypertension, hypoglycemia, preterm birth, postpartum hemorrhage) and neonatal complications in both groups (FGR, macrosomia, deformity, asphyxia, Hypoglycemia, Reflex Sympathetic Dystrophy Syndrome (RSD)]. Results There was no significant difference in FBG and 2h PBG between the two groups before treatment (P> 0.05). After treatment, FBG and 2h PBG in the observation group were lower than those in the control group (P <0.05). Insulin consumption in observation group was less than that in control group, and reference time of blood glucose recovery was shorter than control group (P <0.05). The complication rate in observation group was lower than that in control group (P <0.05). The incidence of neonatal complications in observation group was lower than that in control group (P <0.05). Conclusion Insulin pump short-term intensive treatment of gestational diabetes mellitus is clinically effective, which can effectively control blood sugar levels and reduce the incidence of complications in neonates and neonates.