Modal analysis and seismic response analysis were carried out for the equatorial diagnostic port plug of international thermonuclear experimental reactor (ITER). The aim of the theoretical analysis is to verify structural strength and reliability of the device. The working condition includes one-dimensional seismic wave and two-dimensional seismic wave. Modal analysis of the device shows that primary vibration is inclined to occur in low-order modes. The horizontal (X-direction, Y-direction) maximum vibration appears at the first and the fourth eigen modes, with the natural frequency of 70.59 and 215.88 Hz respectively, and the vertical (Z-direction) primary vibration appears at the second eigen mode with the natural frequency of 82.85 Hz. According to the results of the finite element analysis (FEA) program, the weak portions of the device are distributed in the joint of port body with blanket shielding module (BSM) and inner side wall of ribbed plate for lifting flange, the maximum von Mises stress is 14.8 MPa with the Y-direction seismic wave. In accordance with the design criteria, the destructive effect is far below the failure boundary, and the structural reliability of the equatorial diagnostic port plug can meet the requirements of the design specifications. Modal analysis and seismic response analysis were carried out for the equatorial diagnostic port plug of international thermonuclear experimental reactor (ITER). The aim of the theoretical analysis is to verify structural strength and reliability of the device. The working condition includes one-dimensional seismic wave Modal analysis of the device shows that primary vibration is inclined to occur in low-order modes. The horizontal (X-direction, Y-direction) maximum vibration appears at the first and the fourth eigen modes, with the natural frequency of 70.59 and 215.88 Hz respectively, and the vertical (Z-direction) primary vibration appears at the second eigen mode with the natural frequency of 82.85 Hz. According to the results of the finite element analysis (FEA) program, the weak portions of the device are distributed in the joint of port body with blanket shielding module (BSM) and inner side wall of ribbed plate for lifting flange, the maximum v on Mises stress is 14.8 MPa with the Y-direction seismic wave. In accordance with the design criteria, the destructive effect is far below the failure boundary, and the structural reliability of the equatorial diagnostic port plug can meet the requirements of the design specifications.