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目的 探讨托吡酯联合丙戊酸钠治疗癫 患儿的临床疗效.方法 收集2010年2月至2014年6月我院收治的98例癫 患儿临床资料,将患儿按照抽签法分为对照组(49例)和治疗组(49例),对照组患儿采取托吡酯单一治疗,治疗组患儿采取托吡酯联合丙戊酸钠治疗,比较两组患儿的治疗效果及不良反应情况.结果 治疗组患儿总有效率为95.9％,对照组患儿总有效率为79.6％,差异有统计学意义(P＜0.05);对照组患儿不良反应发生率为8.2％,治疗组患儿不良反应发生率为 6.1％,差异无统计学意义(P＞0.05).结论 托吡酯联合丙戊酸钠治疗癫 患儿疗效明显,无明显不良反应.“,”Objective To investigate the clinical curative effect of topiramate combined with sodium valproate in treatment of children with epilepsy.Methods 98 epileptic patients were randomly selected in 2010 February to 2014 June in our hospital as the research object,according to the draw children were divided into control group(49 cases)and treatment group(49 cases),the control group were taking topiramate monotherapy,in treatment group were taken combined topiramate and valproic acid sodium in the treatment of adverse reactions,and compare the two groups of children with treatment efficacy.Results The treatment group in the total efficiency was 95.9％,control group the total effective rate was 79.6％,the difference was statisticaly significant(P＜0.05);the control group of children with adverse reaction incidence was 8.2％in the treatment group,the adverse reaction incidence was 6.1％,no significant difference(P＞0.05).Conclusion Topiramate combined with sodium valproate in treatment of epilepsy in children with obvious curative effect,no obvious adverse reaction.