盐酸苯海拉明是一种常用的、毒性较小的抗组织胺药物,其糖浆制剂通常用于小儿荨麻疹及其它过敏性疾病。小儿用药要求剂量准确,但糖浆制剂含量测定方法文献报道较少。对于盐酸苯海拉明糖浆的测定,曾报道采用中和滴定法,但终点变化不明显,难以准确地进行测定;另有文献报道用酸性染 Diphenhydramine hydrochloride is a common, less toxic antihistamine that is commonly used in children with urticaria and other allergic diseases. Pediatric medication required dose accuracy, but the method of determination of syrup preparations reported in the literature less. For the determination of diphenhydramine hydrochloride syrup, it has been reported using neutralization titration, but the end point change was not obvious, it is difficult to accurately determine; another reported in the literature with acid dye