论文部分内容阅读
目的探讨血清Ⅳ型胶原(Ⅳ-C)在诊断糖尿病早期肾损害的临床价值。方法应用放射免疫法检测52例2型糖尿病(DM)病人及46例正常对照组血清中Ⅳ-C水平。根据尿蛋白含量不同将52例DM病人分为3组。结果52例DM病人血清中Ⅳ-C水平高于正常对照组(P<0·01),DM各组中血清Ⅳ-C水平随尿蛋白含量增加而增加(r=0·95,P<0·01)。DM各组中血中尿素氮(BUN)、肌酐(Cr)升高不明显,但血中Ⅳ-C升高显著,Ⅳ-C与BUN、Cr呈正相关(BUNr=0·76,Crr=0·70,P均<0·01)。结论通过对糖尿病早期肾损害病人血中Ⅳ-C水平与血BUN、Cr、尿蛋白检测结果比较,来判断DM早期肾损害或肾小球纤维化程度有用指标,同时对DM肾脏损害早期诊断及发生发展具有重要的临床价值。
Objective To investigate the clinical value of serum type Ⅳ collagen (Ⅳ-C) in the diagnosis of early diabetic nephropathy. Methods Serum levels of Ⅳ-C were measured by radioimmunoassay in 52 patients with type 2 diabetes mellitus (DM) and 46 normal controls. According to the different urinary protein content, 52 DM patients were divided into 3 groups. Results The serum levels of Ⅳ-C in 52 DM patients were significantly higher than those in normal controls (P <0.01). The serum levels of IV-C in DM patients increased with the increase of urinary protein (r = 0.95, P <0 · 01). There was no significant increase of BUN and Cr in the DM group, but the level of Ⅳ-C in the blood was significantly increased, and the positive correlation was found between Ⅳ-C and BUN and Cr (BUNr = 0.76, Crr = 0 · 70, P <0.01). Conclusions The level of Ⅳ-C in the blood of diabetic patients with early renal damage and blood BUN, Cr, urinary protein test results to determine the useful indicators of DM early renal damage or glomerular fibrosis, while the early diagnosis of diabetic nephropathy and The occurrence of development has important clinical value.