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粘膜抵御微生物的功能取决于机体的许多因素。在外分泌液的抗体活性中 IgA 是主要的屏障。虽然,大量的 IgA 由骨髓产生,但分泌型和血清型IgA 是两个独立的系统。在血清中主要为 IgA1,而在粘液中 IgA1和 IgA2的分布相同。IgA 肾小球肾炎和膜性肾小球肾炎是免疫复合物介导的肾病,IgA 肾小球肾炎的恶化常与上呼吸道或消化道病毒感染有关,此外还可能与食物抗原有关;而系膜区 IgA 的沉积是否来自粘膜尚有争议.特发性肾病综合征则由 T 细胞功能紊乱,分泌过多的淋巴因子,如血管渗透因子所致。本文旨在研究成人原发性肾小球肾炎时唾液中 IgA 亚类和其它参数的可能变化。病人和方法作者对14例 IgA 肾小球肾炎、14例特发性肾病综合征、8例膜性肾小球肾炎活动
Mucosal resistance to microbial function depends on many factors of the body. IgA is the major barrier in the activity of exocrine fluids. Although a large amount of IgA is produced by the bone marrow, secreted and serogroup IgA are two separate systems. It is mainly IgA1 in serum, while IgA1 and IgA2 are the same in mucus. IgA glomerulonephritis and membranous glomerulonephritis are immune complex-mediated nephropathy, IgA glomerulonephritis often associated with upper respiratory tract or gastrointestinal virus infection, may also be related to food antigens; and mesangial It remains controversial whether the deposition of IgA from the mucosa, or idiopathic nephrotic syndrome, is caused by T-cell dysfunction and excessive secretion of lymphokines, such as vascular permeability factors. This article aims to investigate possible changes in IgA subclasses and other parameters in saliva during adult primary glomerulonephritis. Patients and Methods The author of 14 cases of IgA glomerulonephritis, idiopathic nephrotic syndrome in 14 cases, 8 cases of membranous glomerulonephritis activity