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目的探讨恶性血液病合并肺部侵袭性真菌感染(invasive fungal infection,IFI)的临床特点。方法对31例并发肺部IFI的恶性血液病患者的临床特征进行回顾性分析。结果广谱抗生素使用时间≥7d,IFI出现前中性粒细胞缺乏时间≥7d,中性粒细胞缺乏持续时间≥10d是并发IFI的重要诱因。感染菌种主要为白色念珠菌(占9.7%,3株)、非白色念珠菌(占12.9%,4株)和曲霉菌(29.1%,9株)。虽经抗真菌治疗,仍有8例患者死于呼吸衰竭。结论恶性血液病患者易于发生IFI,且一旦发生病死率明显增加,应及早进行预防和早期经验性抗真菌治疗。
Objective To investigate the clinical features of invasive fungal infection (IFI) in patients with hematologic malignancies. Methods The clinical features of 31 patients with hematologic malignancies complicated by pulmonary IFI were analyzed retrospectively. The results of broad-spectrum antibiotic use time ≥ 7d, IFI appear pre-neutropenia lack of time ≥ 7d, neutrophil lack of duration ≥ 10d is an important cause of concurrent IFI. Infectious bacteria were mainly Candida albicans (9.7%, 3 strains), Candida albicans (12.9%, 4 strains) and Aspergillus (29.1%, 9 strains). Although antifungal therapy, there are still 8 patients died of respiratory failure. Conclusions IFI is prone to occur in patients with hematologic malignancies, and in the event of a marked increase in mortality, prevention and early empirical antifungal therapy should be performed.