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沿用多年静注肼苯哒嗪治疗先兆子痫的方法近期已被淘汰,用其他药物替代。 先兆子痫是一种妊娠特定情况,其特点为高血压、蛋白尿及水肿,偶尔出现凝血障碍或肝功能不良。治疗妊娠高血压的目的是降低血压至一定水平,使孕妇不发生急性脑血管意外合并症的危险且不损伤胎儿。 吞服或咬嚼吞服硝苯吡陡10～20mg可在10～20min内降低血压,很少导致低血压,多普勒波形显示硝苯吡啶不影响子宫胎盘血流及胎儿心率。Fe-nakel 比较了舌下含服硝苯地平10～30mg与静注肼苯达嗪6.25～12.5mg于49例先兆子痫高血压患者,结果使用硝苯地平的96％血压控制,而肼苯达嗪组仅68％。对婴儿的ADR也比后者少。镁离子可加强其降压作用,故使用镁制剂的先兆子痫病人应慎用本品。 口服硝苯吡啶不能有效控制高血压时,静注拉贝洛尔(Labetalol)可有效的控制血压而无周围血管扩张引起的不良反应,但对胎儿的安全性仍有争议。
Follow the years of intravenous hydralazine treatment of preeclampsia has recently been eliminated, replaced with other drugs. Preeclampsia is a pregnancy-specific condition characterized by hypertension, proteinuria and edema, with occasional coagulation disorders or liver dysfunction. The purpose of treatment of pregnancy-induced hypertension is to lower blood pressure to a certain level so that pregnant women do not have the risk of acute cerebrovascular accidental complications without damaging the fetus. Swallowing or crunching swallowing nifedipine steep 10 ~ 20mg 10 ~ 20min can lower blood pressure, rarely lead to hypotension, Doppler waveform showed nifedipine does not affect uterine placental blood flow and fetal heart rate. Fe-nakel compared sublingual naftifine 10 to 30 mg with intravenous hydralazine 6.25 to 12.5 mg in 49 patients with preeclamptic hypertension, the results using nifedipine 96% of the blood pressure control, and hydrazine Up to only 68% of the group. ADR to infants less than the latter. Magnesium ions can enhance its antihypertensive effect, so the use of magnesium preparations of pre-eclampsia patients should be careful with this product. Oral nifedipine is not effective in controlling hypertension, intravenous labetalol can effectively control blood pressure without peripheral vasodilation caused by adverse reactions, but the safety of the fetus is still controversial.