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[目的]观察叶下珠联合阿糖腺苷治疗慢性乙型肝炎(CHB)的临床疗效。[方法]治疗组(34例)在常规保肝药物治疗的基础上用阿糖腺苷(400 mg/d,共30 d),叶下珠片(4~6片/次,3次/d,共3个月);对照组(32例)在常规护肝药物基础上用阿糖腺苷(同治疗组),3个月后观察肝功能、乙肝三系和HBV-DNA的变化。[结果]治疗组和对照组总有效率分别为73.5%和43.7%,HBV-DNA定量检测对数值为3.91±2.09和5.28±1.84,HBeAg转阴率为67.6%和28.1%,差异均有统计学意义(均P<0.01);治疗组丙氨酸氨基转移酶为(69.74±31.05)U/L,对照组为(95.69±59.65)U/L,两组HBeAg/HBeAb血清转换率分别为58.9%和31.2%,差异均有统计学意义(均P<0.05)。[结论]叶下珠联合阿糖腺苷治疗CHB具有良好疗效。
[Objective] To observe the clinical efficacy of Phyllanthus combined with vidarabine in the treatment of chronic hepatitis B (CHB). [Method] The treatment group (34 cases) was treated with adenosine monophosphate (400 mg / d for 30 days), folic acid tablets (4-6 tablets / time, 3 times / d , Three months in total). The control group (32 cases) was given adenosine (same treatment group) on the basis of routine hepatoprotective drugs. After three months, the changes of liver function, hepatitis B three lines and HBV-DNA were observed. [Results] The total effective rates of the treatment group and the control group were 73.5% and 43.7% respectively, the logarithm of HBV-DNA quantitative test was 3.91 ± 2.09 and 5.28 ± 1.84, and the negative rate of HBeAg was 67.6% and 28.1% respectively (69.74 ± 31.05) U / L in the treatment group and (95.69 ± 59.65) U / L in the control group respectively, and the seroconversion rates of HBeAg / HBeAb in the two groups were 58.9 % And 31.2%, respectively (all P <0.05). [Conclusion] Ye Xiazhu combined with adenosine treatment of CHB has a good effect.