【摘 要】
：
Impaired axonal development and degeneration underlie many debilitating diseases,including hereditary spastic paraplegia(HSP).HSPs are a heterogeneous group of neurogenetic disorders characterized by axonopathy of cortical motor neurons(Fink,2006;Blacksto
【机 构】
：
Department of Biomedical Sciences,University of Illinois College of Medicine Rockford,Rockford,IL,US
论文部分内容阅读
Impaired axonal development and degeneration underlie many debilitating diseases,including hereditary spastic paraplegia(HSP).HSPs are a heterogeneous group of neurogenetic disorders characterized by axonopathy of cortical motor neurons(Fink,2006;Blackstone et al.,2010).
其他文献
The approval of oral disease modifying therapies (DMTs) for relapsing-remitting multiple sclerosis (RRMS) has changed considerably the therapeutic scenario and they often represent the first therapeutic choice for patients with RRMS, since their safety an
The formation and preservation of long-term memories critically depend upon coordinated activity of neuronal circuits, intracellular signaling cascades and synaptic remodeling (Josselyn et al., 2015). These essential processes occur in specific cell popul
The amyloid hypothesis of Alzhemer\'s disease (AD) postulates that the generation of amyloid-beta (Aβ) peptide from the amyloid precursor protein (APP) by the action of the γ-secretase complex is one of the principal causes of AD. This idea is supported
Filled with more than 60 different types of hydrolases,the acidic organelle lysosome governs cellular digestion by removing damaged organelles and catabolic products(Xu and Ren,2015).
Alzheimer\'s disease(AD)is one of the major forms of dementia,accounting for 60 to 80％of the cases of dementia,affecting approximately 50 million people worldwide,which is why it has become an object of great interest in both the medical and social fiel
Premature birth,defined as birth before 37 weeks completed gestation,represents 11.1％of all live births worldwide and the rate has increased in almost all countries over the past few decades(Dhillon et al.,2018).
Cerebral ischemia and resultant energy collapse: The ischemic stroke is a complex neurological condition that can be devastating for patients and their families. This disease is the second leading cause of death worldwide and is characterized by a sudden
Introduction of the treatment concept: Regular deep brain stimulation (rDBS) is the standard therapy for the treatment of medically refractory Parkinson\'s disease (PD) (Benabid et al., 2009). Notwithstanding its significant therapeutic effects, rDBS ma
Advances in imaging have led to the development of several new types of microscopes such as serial block face scanning electron microscopy (SBF-SEM), lightsheet microscopy, as well as X-ray micro-computed tomography (micro-CT), which enables the study of
Neurodegenerative disorders are characterized by disruptions to neuronal function and circuitry, leading to a variety of clinical syndromes depending on the affected neuroanatomic regions (Geula, 1998). Many proteinopathies implicated in neurodegenerative