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本文报导19例成人CNL.男16例,女3例,30岁以下者占68%.约半数CNL(40%)发生在白血病确诊后3月内.临床表现以头痛,呕吐最多见.头痛,呕吐与颅内压增高相平行.脑脊液检查,19例中16例细胞数>10个,3例仅表现为脑压增高.本组以MTX鞘内注射作为主要疗法收到良好效果,其缓解率达68%.另外也着重讨论发病率(18%),发病原理,诊断标准及防治措施,强调各型白血病无论在疾病的任何阶段均有并发CNL的可能.CNL亦可反过来浸润骨髓引起全身性复发.因而对CNL防治达到延长缓解期,愈发重要.
In this paper, 19 cases of adult CNL were reported. There were 16 males and 3 females, accounting for 68% of patients under the age of 30. About half of CNL (40%) occurred within 3 months after the diagnosis of leukemia.The clinical manifestations were headache and vomiting, Vomiting and increased intracranial pressure parallel to cerebrospinal fluid examination, 19 cases of 16 cases of cells> 10, 3 cases showed only increased intracranial pressure.This group of MTX intrathecal injection as the main therapy received good results, the response rate of up to 68% .In addition, it also focuses on the incidence (18%), pathogenesis, diagnostic criteria and prevention and treatment, emphasizing that all types of leukemia may have CNL concurrently at any stage of the disease.CNL can in turn infiltrate the bone marrow to cause systemic Relapse.Therefore, to prolong the remission of CNL control, more and more important.