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结核休眠菌是残存于人体巨噬细胞内处于代谢静止期的极微量结核分枝杆菌(MTB),了解其生物学特性和相关作用机制对MTB潜伏感染新靶点药物的研究具有重要意义。巨噬细胞作为机体固有免疫和适应性免疫的重要组成部分,是清除胞内感染的MTB的首要屏障。巨噬细胞可以通过自噬途径清除MTB,而处于休眠状态的MTB可以逃避巨噬细胞的杀伤而持续存在。此外,目前有关休眠菌如何逃逸巨噬细胞自噬的具体机制也并不十分明确,本文则对休眠菌及其与巨噬细胞自噬相关研究的最新进展作一综述。
Mycobacterium tuberculosis is a trace amount of Mycobacterium tuberculosis (MTB) that remains in human macrophages in the quiescent period of metabolism. It is of great significance to understand its biological characteristics and related mechanism of action for the study of MTB latent infection of new target drugs. Macrophages, as an important part of innate immunity and adaptive immunity, are the primary barrier to clear intracellular MTB. Macrophages can clear the MTB by autophagy, while dormant MTB can persist without macrophage killing. In addition, the current mechanism of how hibernation bacteria escape macrophage autophagy is not very clear. In this paper, the recent progress on the study of the relationship between hibernation bacteria and macrophage autophagy was reviewed.