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目的观察整合素αvβ6和CD44v6在胃癌中的表达变化,探讨其临床病理意义。方法采用免疫组织化学En Vision法分别检测72例胃癌组织、20例癌旁正常胃黏膜组织中整合素αvβ6和CD44v6的表达情况,分析二者在胃癌患者分化程度,淋巴结转移方面的相关性。结果胃癌组αvβ6的阳性表达率63.8%显著高于癌旁正常胃黏膜组13%,有淋巴结转移者68.2%显著高于无淋巴结转移者38.0%(P<0.05);胃癌组织CD44v6的阳性表达率45.6%显著高于癌旁胃黏膜0%,有淋巴结转移者48.0%显著高于无淋巴结转移者22.7%(P<0.05);胃癌组织中αvβ6与CD44v6的表达呈正相关(P<0.05)。结论整合素αvβ6和CD44v6在胃癌中的表达呈正相关,二者在胃癌浸润转移过程中发挥协同作用,联合检测整合素αvβ6和CD44v6的表达对胃癌的预后判断有重要的临床病理意义。
Objective To observe the expression changes of integrin αvβ6 and CD44v6 in gastric carcinoma and to explore the clinicopathological significance. Methods The expressions of integrin αvβ6 and CD44v6 in 72 cases of gastric cancer tissue and 20 cases of normal gastric mucosa tissues were detected by immunohistochemistry En Vision method respectively. The correlation between the expression of integrin αvβ6 and CD44v6 in gastric cancer patients with differentiation and lymph node metastasis was analyzed. Results The positive rate of αvβ6 in gastric cancer was 63.8%, which was significantly higher than that in normal gastric mucosa (13.2%). The rate of positive expression of CD44v6 in gastric cancer was significantly higher than that in non-lymph node metastasis (68.2% vs 38.0%, P <0.05) 45.6% were significantly higher than 0% of gastric mucosa adjacent to cancer, 48.0% of those with lymph node metastasis were significantly higher than those without lymph node metastasis (22.7%, P <0.05). There was a positive correlation between the expression of αvβ6 and CD44v6 in gastric cancer (P <0.05). Conclusion The expression of integrin αvβ6 and CD44v6 in gastric cancer is positively correlated. Both of them play a synergistic role in the invasion and metastasis of gastric cancer. The combined detection of integrin αvβ6 and CD44v6 has important clinical and pathological significance in the prognosis of gastric cancer.