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目的：了解糖尿病合并代谢综合征（MS）患者干预6年慢性并发症的发生情况，并探讨 MS 对慢性并发症发生风险的影响。方法选取2008年8月北京劲松社区卫生服务中心就诊的2型糖尿病（T2DM）患者441例，根据是否合并 MS 将患者分为糖尿病合并 MS 组（n =290）和糖尿病组（n =151）。所有患者进行干预随访，每6个月详细记录 BMI、腰围、臀围、腰臀比、颈围、收缩压（ SBP）、舒张压（ DBP）、空腹血糖（ FPG）、餐后2 h 血糖（2 hPG）、糖化血红蛋白（HbA1c ）、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、尿素氮、肌酐、血尿酸，每年记录大血管、微血管并发症发生情况，随访时间为6年。慢性并发症发生的危险因素分析采用 Cox 回归分析。结果（1）糖尿病合并 MS 组慢性并发症总体发生率（17.6%，51/290）高于糖尿病组（9.3%，14/151），差异有统计学意义（P <0.05）；两组 Kaplan _ Meier 生存曲线间差异有统计学意义（χ2=4.82，P =0.028）。（2）Cox 回归分析结果显示，糖尿病合并 MS 患者发生慢性并发症的风险是不合并 MS 患者的1.88倍〔95% CI（1.06，3.85），P =0.031〕；调整性别、年龄、受教育程度后，合并 MS 患者发生慢性并发症的风险是不合并 MS 患者的2.24倍〔95% CI（1.24，4.04），P =0.047〕。（3）糖尿病合并 MS 组干预前 BMI、腰围、臀围、腰臀比、颈围、SBP、DBP、FPG、2 hPG、HbA1c、TG、LDL-C、血尿酸均高于糖尿病组，差异有统计学意义（ P <0.05）；干预后 BMI、腰围、臀围、腰臀比、颈围、FPG、2 hPG、HbA1c 仍高于糖尿病组，差异有统计学意义（ P <0.05）。结论糖尿病合并 MS 患者干预后慢性并发症发生率明显高于不合并 MS 患者，合并 MS 增加了糖尿病患者发生心脑血管疾病的风险。“,”Objective To investigate the occurrence of chronic complications of diabetic patients with metabolic syndrome(MS)after 6 _ year intervention and the influence of MS on the risk of chronic complications. Methods In August 2008,we enrolled 441 T2DM patients who received treatment in Jinsong Community Health Service Center. According to whether patients were complicated with MS,the patients were divided into diabetic with MS group( n = 290)and diabetic group( n= 151). Intervention follow _ up was conducted on all patients,and BMI,waistline,hipline,waist _ hip ratio,neck circumference,SBP,DBP,FPG,2 hPG,HbA1c ,TG,TC,HDL-C,LDL-C,urea nitrogen,creatinine and blood uric acid were recorded every six months. The occurrence rates of great vessel and microvascular complications were recorded each year. And the follow _ up lasted for 6 years. The risk factors for the occurrence of chronic complications were analyzed by Cox regression analysis. Results (1)The incidence of chronic complications of diabetic with MS group was higher than that of diabetic group 〔(17. 6% ,51 / 290)vs. (9. 3% ,14 / 151)〕 (P < 0. 05);the two groups were significantly different in Kaplan _ Meier survival curve( χ2 = 4. 82,P = 0. 028 ) . ( 2 ) The results of Cox regression analysis showed that the risk of chronic complications in diabetic patients complicated with MS was 1. 88 times that of patients without MS complication〔95% CI(1. 06, 3. 85),P = 0. 031〕;after adjustment of gender,age and educational level,the risk of chronic complications in diabetic patients complicated with MS was 2. 24 times that of patients without MS〔95% CI(1. 24,4. 04),P = 0. 047〕. (3)Before intervention,diabetic with MS group was higher than diabetic group in BMI,waistline,hipline,waist _ hip ratio,neck circumference,SBP,DBP,FPG,2 hPG,HbA1c ,TG,LDL-C and blood uric acid( P < 0. 05);after intervention,BMI, waistline,hipline,waist _ hip ratio,neck circumference,FPG,2 hPG,HbA1c were higher than those of diabetic group(P <0. 05). Conclusion Diabetic patients complicated with MS are higher than diabetic patients without MS in the incidence of chronic complications,and the complication of MS increases the risk of cardiovascular and cerebrovascular diseases.