论文部分内容阅读
胰岛素是一种常用降糖药,但直接将胰岛素口服给药,可使其在胃肠道被蛋白酶迅速降解,因此临床通常采用注射给药,但注射给药给病人带来诸多不便。近年来,非注射给药途径的胰岛素制剂已成为研究热点。随着国内外对胰岛素制剂的深入研究和药剂工业的发展,胰岛素非注射给药系统研究的发展十分迅速,取得了很大的进展。根据中医的研究理论可知,糖尿病早期以阴虚燥热型及气阴两虚型为多见,中药对于糖尿病的胰岛素功能、胰岛素抵抗及症状均有改善作用。中药联合胰岛素治疗可以更有效地控制糖尿病病情,减少并发症,能取得更好的治疗效果。全文介绍了胰岛素的口服、透皮、黏膜、肺部等非注射给药系统,并阐述了中药联合胰岛素治疗阴虚燥热型糖尿病的研究进展。
Insulin is a commonly used hypoglycemic drug, but oral administration of insulin directly, it can be quickly degraded in the gastrointestinal tract by protease, so the clinical injection is usually used, but the injection to the patient to bring a lot of inconvenience. In recent years, non-injectable route of insulin preparation has become a research hotspot. With the in-depth study of insulin preparations at home and abroad and the development of pharmacy industry, the research on insulin non-injection delivery system has developed rapidly and great progress has been made. According to the theory of traditional Chinese medicine, it can be seen that in the early stages of diabetes, the symptoms of yin deficiency, dryness type and deficiency of qi and yin are more common. Chinese medicine can improve the insulin function, insulin resistance and symptoms of diabetes mellitus. Chinese medicine combined with insulin treatment can more effectively control the condition of diabetes, reduce complications, can achieve better therapeutic effect. The paper introduces the non-injection delivery system of insulin, such as oral, transdermal, mucosal and pulmonary, and expounds the research progress of traditional Chinese medicine combined with insulin in the treatment of Yin-deficiency and heat-dampness diabetes.