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目的探讨高龄老年多原发恶性肿瘤(multiple primary neoplasms,MPN)临床特点,提高对老年MPN的认识。方法回顾性分析65例高龄MPN患者的临床资料。结果调查老年恶性肿瘤患者472例,其中MPN65例,占13.8%。确诊第一肿瘤时中位年龄76岁。发病最常见的系统为呼吸、消化及泌尿生殖系统,最常见的器官为肺、胃及前列腺。组织病理学最常见的实体瘤依次是腺癌、移行细胞癌及鳞癌。中位生存时间69月。同时性MPN及异时性MPN在生存时间上差异无显著性(P=0.42)。二原发异时性MPN两肿瘤中位间隔时间88月,≥5年组及<5年组生存时间差异无显著性(P=0.87)。结论老年人MPN发病率明显升高,但恶性程度相对较低,生存时间长,应得到足够的重视。
Objective To investigate the clinical features of multiple primary neoplasms (MPN) in elderly patients and to improve their understanding of the elderly MPN. Methods The clinical data of 65 elderly patients with MPN were retrospectively analyzed. Results 472 elderly patients with malignant tumors were investigated, including 65 cases of MPN, accounting for 13.8%. The median age at diagnosis of the first tumor was 76 years. The most common diseases are respiratory, digestive and genitourinary systems. The most common organs are lung, stomach and prostate. The most common histopathological solid tumors followed by adenocarcinoma, transitional cell carcinoma and squamous cell carcinoma. The median survival time in 69 months. There was no significant difference in survival time between MPN and MPN (P = 0.42). There were no significant differences in the survival time between the two primary metachronous MPN tumors in 88 months, ≥ 5 years and <5 years (P = 0.87). Conclusion The incidence of MPN in the elderly is obviously increased, but the malignant degree is relatively low and the survival time is long, which deserves enough attention.