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目的探讨腹腔镜联合阿那曲唑治疗子宫内膜异位症的临床治疗效果。方法选取60例子宫内膜异位症患者随机分为手术组(30例)和手术药组(30例)。采用两种不同的治疗方式并在治疗后抽取患者空腹时肘静脉血2mL,血清测定其CAl25水平,采用放射免疫法检测血清中雌二醇(E2)水平,应用免疫组化方法检测两组患者子宫内膜组织中细胞色素芳香化酶(P450arom)、雌激素及其受体(ER)水平的表达,观察其治疗效果。结果手术药组总有效率为95%,明显高于手术组总有效率70%;两组患者治疗后血清CAl25含量比较,差别有统计学意义(P<0.01);手术药组血循环中E2、P450arom和ER表达下降幅度大于手术组,差异有统计学意义(P<0.01)。结论腹腔镜手术联合阿那曲唑药物治疗子宫内膜异位症的效果明显优于单纯腹腔镜手术。
Objective To investigate the clinical effect of laparoscopy combined with anastrozole in the treatment of endometriosis. Methods Sixty patients with endometriosis were randomly divided into operation group (30 cases) and operation drug group (30 cases). Two different treatment methods were used and 2 mL of elbow venous blood was collected after fasting. Serum levels of CA125 were measured. Serum estradiol (E2) levels were measured by radioimmunoassay. Immunohistochemistry was used to detect the levels of CA125 in both groups Endometrial tissue cytochrome aromatase (P450arom), estrogen and its receptor (ER) levels, to observe the therapeutic effect. Results The total effective rate of the operation group was 95%, which was significantly higher than that of the operation group. The total effective rate of the operation group was 70%. The serum CA125 levels in the two groups were significantly different (P <0.01) The decrease of P450arom and ER expression was greater than that of the operation group, the difference was statistically significant (P <0.01). Conclusion Laparoscopic surgery combined with Anastrozole treatment of endometriosis was significantly better than simple laparoscopic surgery.