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内毒素及其诱导产物如IL-1、PAF、TNF等可损伤血管内皮细胞、降低脂蛋白酯酶活性使血浆甘油三酯浓度升高、促使巨噬细胞内胆固醇酯的合成、抑制纤溶活性、改变血液凝固状态及促进PDGF样分裂原的产生等。内毒素的这些生物学作用与动脉粥样硬化的发病机制密切相关,故有人提出内毒素可能参与动脉粥样硬化形成。
Endotoxin and its induced products such as IL-1, PAF, TNF, etc. can damage vascular endothelial cells, reduce lipoprotein lipase activity so that the concentration of plasma triglycerides, macrophages to promote cholesterol ester synthesis, inhibition of fibrinolytic activity , Change the state of blood coagulation and promote the generation of PDGF-like mitogen. These biological effects of endotoxin are closely related to the pathogenesis of atherosclerosis. Therefore, it has been suggested that endotoxin may be involved in the formation of atherosclerosis.