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目的:观察乌司他丁对西宁地区急性肺损伤(ALI)的疗效。方法:将50例急性肺损伤患者,随机分为两组,实验组25例,对照组25例,所有患者均行ICU综合治疗,实验组加用乌司他丁,观察两组患者呼吸频率(RR)、血气指标、急性生理和慢性健康状况评分Ⅱ(APACHEⅡ评分)、急性呼吸窘迫综合征(ARDS)发生率及死亡率变化。结果:治疗第7天实验组患者RR、APACHEⅡ评分、动脉血氧分压(PaO2)、氧合指数(PaO2/FiO2)较对照组明显改善(P<0.05),两组间ARDS发生率及死亡率比较差异均有统计学意义(P<0.05)。结论:乌司他丁能显著改善西宁地区急性肺损伤患者的氧合,降低ARDS发生率,对改善预后有积极的作用。
Objective: To observe the effect of ulinastatin on acute lung injury (ALI) in Xining area. Methods: Fifty patients with acute lung injury were randomly divided into two groups: experimental group (25 cases) and control group (25 cases). All patients underwent ICU combined treatment. The experimental group was given ulinastatin, and the respiratory rate RR), blood gas index, acute physiology and chronic health status Ⅱ (APACHEⅡscore), acute respiratory distress syndrome (ARDS) incidence and mortality. Results: The RR, APACHEⅡscore, PaO2 and PaO2 / FiO2 in the experimental group on the 7th day of treatment were significantly improved compared with the control group (P <0.05). The incidence and mortality of ARDS The differences were statistically significant (P <0.05). Conclusion: Ulinastatin can significantly improve oxygenation and reduce the incidence of ARDS in patients with acute lung injury in Xining, and has a positive effect on the prognosis.