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目的本为旨在探讨β2-微球蛋白在糖尿病肾病早期诊断中的临床价值。方法将入选患者根据糖尿病病程分为DMⅠ组(病程≥5年)与DMⅡ组(病程<5年),利用免疫比浊法检测患者血清和尿液中β2-微球蛋白水平。结果与正常对照组相比,DMⅠ组和DMⅡ组糖尿病患者血清及尿液β2-微球蛋白水平均有显著性增加(P<0.05);在所检测的115份尿液样本中,尿白蛋白正常的患者(<20 mg/L)有45例,尿微量白蛋白(20～200 mg/L)有70例,所检测出其中尿β2-微球蛋白增高共78例,血清β2-微球蛋白水平增高共68例。结论β2-微球蛋白水平对糖尿病肾病的早期诊断具有重要的意义,可提高糖尿病早期肾功能损害的检出率,可在临床上广泛推广应用的检测方法。
Purpose This purpose is to investigate the clinical value of β2-microglobulin in the early diagnosis of diabetic nephropathy. Methods According to the duration of diabetes, the patients were divided into DM Ⅰ group (duration ≥ 5 years) and DM Ⅱ group (duration <5 years). The levels of β2-microglobulin in serum and urine of patients were detected by immunoturbidimetry. Results Compared with the normal control group, the levels of β2-microglobulin in serum and urine of diabetic patients with DMⅠ and DMⅡ were significantly increased (P <0.05). Among the 115 urine samples tested, urinary albumin 45 cases of normal patients (<20 mg / L), 70 cases of urine microalbuminuria (20-200 mg / L), which detected 78 cases of urinary β2-microglobulin increased in serum β2-microglobulin A total of 68 cases of protein levels increased. Conclusion The level of β2-microglobulin has an important significance in the early diagnosis of diabetic nephropathy, which can increase the detection rate of early renal damage in diabetes and can be widely applied in clinical practice.