热休克蛋白是细胞受各种应激原刺激后诱导产生的一组应激蛋白 ,具有维持细胞蛋白稳定、促进细胞生存等功能 ,在细胞生长、发育、分化、基因转录等方面发挥重要作用 .近年来发现热休克蛋白也与肿瘤细胞的发生、发展密切相关 .在多种肿瘤组织中发现热休克蛋白存在高表达 ,尤其在乳腺癌中与患者预后密切相关 .本文就热休克蛋白的结构、生物学功能、致癌机理以及与乳腺癌的关系作一概述 . Heat shock protein is a group of stress proteins induced by various stress stimuli. It has the functions of maintaining cell protein stability, promoting cell survival and plays an important role in cell growth, development, differentiation and gene transcription. In recent years, it has been found that heat shock proteins are also closely related to the occurrence and development of tumor cells.Hepatic shock protein is highly expressed in many tumor tissues, especially in breast cancer patients with prognosis of patients.This paper studied the structure of heat shock proteins, Biological function, carcinogenic mechanism and the relationship with breast cancer.