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为比较阴道内和宫颈内前列腺素凝胶促宫颈成熟和引产的效果,日内瓦大学医院妇产科自1994年6月～1995年10月,将247例单胎妊娠的孕妇,随机分为阴道凝胶组(n=125)与宫颈内凝胶组(n=122)。两种凝胶均由瑞典Upjohn公司提供,阴道组给予阴道内前列腺素E_2(PGE_2)凝胶2mg,宫颈组给予宫颈内PGE_2凝胶0.5mg,6小时后如果Bishop评分仍是4分或<4分,再给予1次,直到第二天,相隔6小时,2次/d,如Bishop评分≥5分,仍无自发临产或第三天未临产者,开始催产素静滴引产。 两组孕妇年龄,胎龄,产次,引产的指征、Bishop评分、血红蛋白、胎儿先露和体重均相似,从第1次给予PGE_2凝胶后,Bishop评分增加3分或更多,阴道组较宫颈组所需时间明显缩短(无层化P=0.05。产次层化后P=0.03)阴道组初产妇需用15小时,经产
To compare the efficacy of intravaginal and intra-cervical prostaglandin gels for cervical ripening and induction of labor, 247 pregnant women with singleton pregnancies were randomly assigned to vaginal coagulation from June 1994 to October 1995 at the University Hospital Geneva, Glue group (n = 125) and cervical gel group (n = 122). Both types of gel were supplied by Upjohn Company in Sweden. Vaginal group received intravaginal PGE 2 gel 2 mg and cervix group intrauterine PGE 2 gel 0.5 mg. After 6 hours, if Bishop score was still 4 or 4 Points, and then given 1, until the next day, 6 hours apart, 2 times / d, such as the Bishop score ≥ 5 points, still no spontaneous or third day without labor, began oxytocin intravenous infusion. Age, gestational age, parity, induction of labor, Bishop score, hemoglobin, fetal exposure and body weight were similar between the two groups. Bishop score increased by 3 points or more after the first administration of PGE 2 gel. Cervical group than the required time was significantly shorter (non-stratified P = 0.05. Sublayer produced after P = 0.03) vaginal primipara required 15 hours, by the production