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It has been proven by experiments that cations play a very important role in metallothioneins polymerization. In this paper, three kinds of metallothioneines including MT-Ⅱfrom rat liver, MT-Ⅰand MT-Ⅱfrom rabbit have been investigated.From the analyses of electrostatic potential, two binding sites of cations can be determined:The first one is located between the dimer interface; the other one is located in the negative electrostatic potential hole.The binding capacity between two monomers in a dimer can be regulated by these cations to some extent.
It has been proven by experiments that cations play a very important role in metallothioneins polymerization. In this paper, three kinds of metallothioneines including MT-II from rat liver, MT-I and MT-II from rabbit have been investigated. From the analysis of electrostatic potential, two binding sites of cations can be determined: The first one is located between the dimer interface; the other one is located in the negative electrostatic potential hole. The binding capacity between two monomers in a dimer can be regulated by these cations to some extent.