发展合成具有多种功能基团的手性非天然氨基酸具有重要的药物化学意义,同时将其设计引入到多肽片段中也是发展新的多肽药物的重要策略和方法.手性α-羟基-β-氨基酸是许多具有药物活性多肽的关键组成单元,也是一些复杂天然产物的组成部分,如紫杉醇(taxol)的侧链结构就是顺式的手性α-羟基-β-氨基酸,而其也是构成leuhistin的核心骨架.虽然对于合成α-羟基-β-氨基酸已经发展了多种 The development of synthetic chiral non-natural amino acids with various functional groups has important pharmacochemical significance, meanwhile introducing its design into polypeptide fragments is also an important strategy and method to develop new peptide drugs.Chiral α-hydroxy-β- Amino acids are the key building blocks of many peptides with pharmaceutical activity and are also part of complex natural products such as the side chain structure of taxol, which is the cis-chiral α-hydroxy-β-amino acid, which is also the constituent of leuhistin Core skeletons Although many have been developed for the synthesis of α-hydroxy-β-amino acids